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Sociedade Brasileira de Patologia Clínica, Jornal Brasileiro de Patologia e Medicina Laboratorial, 4(52)

DOI: 10.5935/1676-2444.20160042

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Quantitative analysis of inflammatory and adhesion molecules in lungs of neonates with chronic lung disease (bronchopulmonary dysplasia) receiving mechanical ventilation

Journal article published in 2016 by Cristina T. Okamoto, Okamoto,Cristina T., Oldenburg Neto,Carlos F., Carlos F. Oldenburg Neto, Sandra Mara Witkowski, Witkowski,Sandra Mara, Percicote,Ana Paula, Ana Paula Percicote, Luca R. Pasqualotto, Pasqualotto,Luca R., Gabriela Troiano, Troiano,Gabriela, Tammy Almeida, Almeida,Tammy, Souza,Cleber M. and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT INTRODUCTION: Chronic lung disease (CLD), clinically known as bronchopulmonary dysplasia (BPD), is a major cause of morbidity in premature newborn and were submitted to oxygen therapy. OBJECTIVE: Immunohistochemical identification of inflammatory molecules in the lung tissue of premature neonates that died with CLD. METHODS: Immunohistochemical analysis of 51 samples of premature newborn lungs – grouped in: without CLD,"classic" CLD and"new" CLD. RESULTS: Neutrophil influx and the number of CD4+ and CD45RO+ cells were higher in the"classic" CLD group (p