A method to retrieve soil moisture (SM) from Advanced Scanning Microwave Radiometer—Earth Observing System Sensor (AMSR-E) observations using Soil Moisture and Ocean Salinity (SMOS) Level 3 SM as a reference is discussed. The goal is to obtain longer time series of SM with no significant bias and with a similar dynamical range to that of the SMOS SM dataset. This method consists of training a neural network (NN) to obtain a global non-linear relationship linking AMSR-E brightness temperatures ( T b ) to the SMOS L3 SM dataset on the concurrent mission period of 1.5 years. Then, the NN model is used to derive soil moisture from past AMSR-E observations. It is shown that in spite of the different frequencies and sensing depths of AMSR-E and SMOS, it is possible to find such a global relationship. The sensitivity of AMSR-E T b ’s to soil temperature ( T s o i l ) was also evaluated using European Centre for Medium-Range Weather Forecast Interim/Land re-analysis (ERA-Land) and Modern-Era Retrospective analysis for Research and Applications-Land (MERRA-Land) model data. The best combination of AMSR-E T b ’s to retrieve T s o i l is H polarization at 23 and 36 GHz plus V polarization at 36 GHz. Regarding SM, several combinations of input data show a similar performance in retrieving SM. One NN that uses C and X bands and T s o i l information was chosen to obtain SM in the 2003–2011 period. The new dataset shows a low bias (