Published in
Wiley, Clinical and Experimental Pharmacology and Physiology, 7(37), p. 684-688, 2010
DOI: 10.1111/j.1440-1681.2010.05372.x
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Inhibition of glycogen synthase kinase 3β prevents peroxide-induced collapse of mitochondrial membrane potential in rat ventricular myocytes
Journal article published in 2010 by
Karina Förster,
Heike Richter,
Mikhail F. Alexeyev,
Dieter Rosskopf,
Stephan B. Felix,
Thomas Krieg 
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Abstract
1. Preconditioning has been proposed to protect the myocardium by inhibiting glycogen-synthase kinase (GSK) 3β. The aim of the present study was to test whether transfection of ventricular myocytes with inactive GSK3β would mimic preconditioning and whether a constitutively active form of GSK3β would prevent protection by an opioid receptor agonist.