Links
Tools
Loss of adipose triglyceride lipase is associated with human cancer and induces mouse pulmonary neoplasia
Journal article published in 2016 by
Wael Al-Zoughbi,
Martin Pichler 
,
Gregor Gorkiewicz ,
Barbara Guertl-Lackner,
Johannes Haybaeck,
Stephan W. Jahn,
Carolin Lackner,
Bernadette Liegl-Atzwanger,
Helmut Popper,
Silvia Schauer,
Elisa Nusshold,
Alida S. D. Kindt,
Zlatko Trajanoski,
Michael R. Speicher ,
Guenther Haemmerle
and other authors.
,
Gregor Gorkiewicz ,
Barbara Guertl-Lackner,
Johannes Haybaeck,
Stephan W. Jahn,
Carolin Lackner,
Bernadette Liegl-Atzwanger,
Helmut Popper,
Silvia Schauer,
Elisa Nusshold,
Alida S. D. Kindt,
Zlatko Trajanoski,
Michael R. Speicher ,
Guenther Haemmerle
and other authors.
Abstract
Metabolic reprogramming is a hallmark of cancer. Understanding cancer metabolism is instrumental to devise innovative therapeutic approaches. Anabolic metabolism, including the induction of lipogenic enzymes, is a key feature of proliferating cells. Here, we report a novel tumor suppressive function for adipose triglyceride lipase (ATGL), the rate limiting enzyme in the triglyceride hydrolysis cascade.