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Targeting hypoxic microenvironment of pancreatic xenografts with the hypoxia-activated prodrug TH-302
Journal article published in 2016 by
Ines Lohse,
Joanna Rasowski,
Pinjiang Cao,
Melania Pintilie,
Trevor Do,
Ming-Sound Tsao 
,
Richard P. Hill,
David W. Hedley
,
Richard P. Hill,
David W. Hedley
Abstract
Previous reports have suggested that the hypoxic microenvironment provides a niche that supports tumor stem cells, and that this might explain clinical observations linking hypoxia to metastasis. To test this, we examined the effects of a hypoxia-activated prodrug, TH-302, on the tumor-initiating cell (TIC) frequency of patient-derived pancreatic xenografts (PDX).