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Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma
Journal article published in 2016 by
Talya L. Dayton 
,
Vasilena Gocheva,
Kathryn M. Miller,
William J. Israelsen,
Arjun Bhutkar,
Clary B. Clish,
Shawn M. Davidson,
Alba Luengo,
Roderick T. Bronson,
Tyler Jacks,
Matthew G. Vander Heiden
,
Vasilena Gocheva,
Kathryn M. Miller,
William J. Israelsen,
Arjun Bhutkar,
Clary B. Clish,
Shawn M. Davidson,
Alba Luengo,
Roderick T. Bronson,
Tyler Jacks,
Matthew G. Vander Heiden
Abstract
In this study, Dayton et al. generated mice lacking PKM2, an isoform of pyruvate kinase, and found that, over time, the mice develop a metabolic syndrome that leads to spontaneous hepatocellular carcinomas (HCCs). These results provide new insights into the role of PKM2 in the regulation of systemic metabolic homeostasis and inflammation.