PURPOSE. To examine the association between central corneal thickness (CCT) and glaucoma.METHODS. This was a nested case-control study using 1090 subjects from an eye disease population survey in Singapore and 243 participants from a hospital glaucoma surgery clinical trial in Singapore.RESULTS. Mean CCT in 938 community subjects was 539 mu m +/- 32 mu m, and in 12 community subjects with primary open angle glaucoma (POAG) the mean CCT was 545 mu m +/- 38 mu m. In the hospital cohort, mean CCT was 552 mu m +/- 38 mu m in 138 patients with POAG and 551 mu m +/- 33 mu m in 105 patients with primary angle closure glaucoma (PACG). No individuals had undergone previous intraocular surgery or had other significant ocular pathology. Regression models showed POAG diagnosis was not associated with CCT (P = 0.42) or age (P = 0.062) in community subjects but was associated with IOP (P = 0.005). Similar analyses for hospital cases showed CCT to be significantly higher in both POAG and PACG (both P = 0.001), but this became nonsignificant after controlling for IOP and age (P = 0.26, POAG; P = 0.08, PACG). Both age (P = 0.043) and IOP (P = 0.001) were highly associated with hospital POAG; only IOP (P = 0.001) was associated with hospital PACG. Further regression analyses for community subjects showed diabetic status and pseudophakia had no significant effect on CCT (P = 0.33 and P = 0.11, respectively).CONCLUSIONS. The authors found no evidence to support the previous observation that thinner corneas may be independently associated with POAG or PACG. Age and IOP are significantly associated with CCT, and this should be taken into account by future studies investigating CCT as an independent risk factor for glaucoma diagnosis. (Invest Ophthalmol Vis Sci. 2011;52:8407-8412) DOI: 10.1167/iovs.11-7927