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Nature Research, Nature Medicine, 10(22), p. 1090-1093, 2016

DOI: 10.1038/nm.4161

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Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[(18)F]fluoro-D-glucose positron emission and computed tomography

Journal article published in 2016 by Hanif Esmail, Db Young, Rp Lai, Rj Wilkinson ORCID, Maia Lesosky ORCID, Ka Wilkinson, Cm Graham, Ak Coussens ORCID, Tolu Oni, Jm Warwick, Qonita Said-Hartley, Cf Koegelenberg, Gerhard Walzl, Jl Flynn, Ce Barry and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Tuberculosis is classically divided into states of latent infection and active disease. Using combined positron emission and computed tomography in 35 asymptomatic, antiretroviral-therapy-naive, HIV-1-infected adults with latent tuberculosis, we identified ten individuals with pulmonary abnormalities suggestive of subclinical, active disease who were substantially more likely to progress to clinical disease. Our findings challenge the conventional two-state paradigm and may aid future identification of biomarkers that are predictive of progression.