Published in
Wiley, Angewandte Chemie International Edition, 44(51), p. 11162-11165, 2012
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Isotope-Based Analysis of Modified tRNA Nucleosides Correlates Modification Density with Translational Efficiency**
Journal article published in 2012 by
Caterina Brandmayr,
Mirko Wagner,
Tobias Brückl,
Daniel Globisch,
David Pearson,
Andrea Christa Kneuttinger,
Veronika Reiter,
Antje Hienzsch,
Susanne Koch,
Ines Thoma,
Peter Thumbs,
Stylianos Michalakis,
Markus Müller,
Martin Biel,
Thomas Carell 
This paper is available in a repository.
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Abstract
Useful diversity: Quantification of modified tRNA nucleobases in different murine and porcine tissues reveals a tissue-specific overall modification content. The modification content correlates with rates of protein synthesis in vitro, suggesting a direct link between tRNA modification levels and tissue-specific translational efficiency.