Published in
Nature Research, Nature Neuroscience, 9(17), p. 1153-1155, 2014
DOI: 10.1038/nn.3778
Links
- ORCID
- Nature Research | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [europepmc.org] | PDF
- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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Beyond Genotype: Serotonin Transporter Epigenetic Modification Predicts Human Brain Function
,
Sandro Galea,
Chiou-Miin Wang,
Marianne L. Seney,
Etienne Sibille,
Douglas E. Williamson,
Ahmad R. Hariri
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Abstract
We examined epigenetic regulation in regards to behaviorally and clinically relevant human brain function. Specifically, we found that increased promoter methylation of the serotonin transporter gene predicted increased threat-related amygdala reactivity and decreased mRNA expression in postmortem amygdala tissue. These patterns were independent of functional genetic variation in the same region. Furthermore, the association with amygdala reactivity was replicated in a second cohort and was robust to both sampling methods and age.