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Springer, Diabetologia, 8(59), p. 1702-1713, 2016

DOI: 10.1007/s00125-016-3973-9

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Excess maternal transmission of variants in the THADA gene to offspring with type 2 diabetes

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Genome-wide association studies (GWAS) have identified more than 65 genetic loci associated with risk of type 2 diabetes. However, the contribution of distorted parental transmission of alleles to risk of type 2 diabetes has been mostly unexplored. Our goal was therefore to search for parent-of-origin effects (POE) among type 2 diabetes loci in families.