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Wiley, Angewandte Chemie International Edition, 3(53), p. 810-814, 2013

DOI: 10.1002/anie.201307232

Wiley, Angewandte Chemie, 3(126), p. 829-833, 2013

DOI: 10.1002/ange.201307232

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Lactose as a “Trojan Horse” for Quantum Dot Cell Transport**

Journal article published in 2013 by David Benito-Alifonso, Shirley Tremel, Bo Hou, Harriet Lockyear, Judith Mantell, David J. Fermin, Paul Verkade, Monica Berry, M. Carmen Galan, M. Carmen Galan ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

A series of glycan-coated quantum dots were prepared to probe the effect of glycan presentation in intracellular localization in HeLa and SV40 epithelial cells. We show that glycan density mostly impacts on cell toxicity, whereas glycan type affects the cell uptake and intracellular localization. Moreover, we show that lactose can act as a “Trojan horse” on bi-functionalized QDs to help intracellular delivery of other non-internalizable glycan moieties and largely avoid the endosomal/lysosomal degradative pathway.