Assays for qualification and quality stratification of clinical biospecimens used in research: A technical report from the ISBER Biospecimen Science Working Group
Journal article published in 2016 by
Fay Betsou 
,
Alexandre Bulla,
Sang Yun Cho,
Judith Clements,
Rodrigo Chuaqui,
Domenico Coppola,
Yvonne De Souza,
Annemieke De Wilde,
William Grizzle,
Fiorella Guadagni,
Elaine Gunter,
Stacey Heil,
Verity Hodgkinson,
Joseph Kessler,
Michael Kiehntopf
and other authors.
,
Alexandre Bulla,
Sang Yun Cho,
Judith Clements,
Rodrigo Chuaqui,
Domenico Coppola,
Yvonne De Souza,
Annemieke De Wilde,
William Grizzle,
Fiorella Guadagni,
Elaine Gunter,
Stacey Heil,
Verity Hodgkinson,
Joseph Kessler,
Michael Kiehntopf
and other authors.
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Abstract
This technical report presents quality control (QC) assays that can be performed in order to qualify clinical biospecimens that have been biobanked for use in research. Some QC assays are specific to a disease area. Some QC assays are specific to a particular downstream analytical platform. When such a qualification is not possible, QC assays are presented that can be performed to stratify clinical biospecimens according to their biomolecular quality.