The exposome is defined as the totality of all hu-man environmental exposures from conception to death. It is often regarded as the complement to the genome, with the interaction between the exposome and the genome ultimately determining one’s phe-notype. The ‘toxic exposome ’ is the complete col-lection of chronically or acutely toxic compounds to which humans can be exposed. Considerable interest in defining the toxic exposome has been spurred on by the realization that most human in-juries, deaths and diseases are directly or indi-rectly caused by toxic substances found in the air, water, food, home or workplace. The Toxin-Toxin-Target Database (T3DB- www.t3db.ca) is a resource