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Wiley, Immunological Reviews, 1(258), p. 132-144, 2014

DOI: 10.1111/imr.12146

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Inflammatory triggers of acute rejection of organ allografts

Journal article published in 2014 by Daniel N. Mori, Daniel Kreisel, James N. Fullerton ORCID, Derek W. Gilroy, Daniel R. Goldstein ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Solid organ transplantation is a vital therapy for end stage diseases. Decades of research has established that the components of the adaptive immune system are critical for transplant rejection, but the role of the innate immune system in organ transplantation is just emerging. Accumulating evidence indicates that the innate immune system is activated at the time of organ implantation by the release of endogenous inflammatory triggers. This review discusses the nature of these triggers in organ transplantation and also potential mediators that may enhance inflammation resolution after organ implantation.