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BioMed Central, World Journal of Emergency Surgery, 1(8), 2013

DOI: 10.1186/1749-7922-8-1

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Complicated intra-abdominal infections in a worldwide context: an observational prospective study (CIAOW Study)

Journal article published in 2013 by Salomone di Saverio ORCID, Massimo Sartelli, Fausto Catena, Luca Ansaloni ORCID, Ernest Moore, Mark Malangoni, George Velmahos, Raul Coimbra ORCID, Kaoru Koike, Ari Leppaniemi, Walter Biffl, Zsolt Balogh, Cino Bendinelli, Sanjay Gupta, Yoram Kluger and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Despite advances in diagnosis, surgery, and antimicrobial therapy, mortality rates associated with complicated intra-abdominal infections remain exceedingly high. The World Society of Emergency Surgery (WSES) has designed the CIAOW study in order to describe the clinical, microbiological, and management-related profiles of both community- and healthcare-acquired complicated intra-abdominal infections in a worldwide context. The CIAOW study (Complicated Intra-Abdominal infection Observational Worldwide Study) is a multicenter observational study currently underway in 57 medical institutions worldwide. The study includes patients undergoing surgery or interventional drainage to address complicated intra-abdominal infections. This preliminary report includes all data from almost the first two months of the six-month study period. Patients who met inclusion criteria with either community-acquired or healthcare-associated complicated intra-abdominal infections (IAIs) were included in the study. 702 patients with a mean age of 49.2 years (range 18-98) were enrolled in the study. 272 patients (38.7%) were women and 430 (62.3%) were men. Among these patients, 615 (87.6%) were affected by community-acquired IAIs while the remaining 87 (12.4%) suffered from healthcare-associated infections. Generalized peritonitis was observed in 304 patients (43.3%), whereas localized peritonitis or abscesses was registered in 398 (57.7%) patients.The overall mortality rate was 10.1% (71/702). The final results of the CIAOW Study will be published following the conclusion of the study period in March 2013. ; Journal Article;