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Society of Nuclear Medicine, Journal of Nuclear Medicine, 10(52), p. 1608-1615, 2011

DOI: 10.2967/jnumed.111.092098

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Targeting the Internal Epitope of Prostate-Specific Membrane Antigen with 89Zr-7E11 Immuno-PET

Journal article published in 2011 by Alessandro Ruggiero, Jason P. Holland ORCID, Tvrtko Hudolin, Larissa Shenker, Anna Koulova, Neil H. Bander, Jason S. Lewis, Jan Grimm
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The potential of the positron-emitting 89Zr has been recently investigated for the design of radioimmunoconjugates for immuno-PET. In this study, we report the preparation and in vivo evaluation of 89Zr-desferrioxamine B (DFO)-7E11, a novel 89Zr-labeled monoclonal antibody (mAb) construct for targeted imaging of prostate-specific membrane antigen (PSMA), a prototypical cell surface marker highly overexpressed in prostate cancer. The ability of 89Zr-DFO-7E11 to delineate tumor response to therapy was also investigated, because it binds to the intracellular epitope of PSMA, which becomes available only on membrane disruption in dead or dying cells.