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American Chemical Society, ACS Applied Materials and Interfaces, 27(8), p. 17047-17059, 2016

DOI: 10.1021/acsami.6b02936

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A Fluorescent Polymer Probe with High Selectivity toward Vascular Endothelial Cells for and beyond Noninvasive Two-Photon Intravital Imaging of Brain Vasculature

Journal article published in 2016 by B. Mettra, F. Appaix, J. Olesiak-Banska ORCID, T. Le Bahers, A. Leung, K. Matczyszyn ORCID, M. Samoc, B. Van Der Sanden, C. Monnereau, C. Andraud
This paper was not found in any repository; the policy of its publisher is unknown or unclear.
This paper was not found in any repository; the policy of its publisher is unknown or unclear.

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Abstract

A chromophore-engineering strategy that relies on the introduction of a ground-state distortion in a quadrupolar chromophore was used to obtain a quasi-quadrupolar chromophore with red emission and large two-photon absorption (2PA) cross-section in polar solvents. This molecule was functionalized with water-solubilizing polymer chains. It constitutes not only a remarkable contrast agent for intravital two-photon microscopy of the functional cerebral vasculature in a minimally invasive configuration but presents intriguing endothelial staining ability that makes it a valuable probe for premortem histological staining.