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Oxford University Press (OUP), Clinical Infectious Diseases, 12(63), p. 1645-1654

DOI: 10.1093/cid/ciw645

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Suboptimal viral suppression rates among HIV-infected children in low- and middle-income countries: a meta-analysis

Journal article published in 2016 by Ragna S. Boerma, Anton P. Bussink, Job C. J. Calis, T. Sonia Boender ORCID, Silvia Bertagnolio, Kim C. E. Sigaloff, Tobias F. Rinke de Wit, Michael Boele van Hensbroek
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Journal Article ; The 90-90-90 goals aim to achieve viral suppression in 90% of all HIV-infected people on antiretroviral treatment (ART), which is especially challenging in children. Global estimates of viral suppression among children in low- and middle-income countries (LMIC) are lacking. This study summarizes viral suppression rates in children on first-line ART in LMIC since the year 2000. We searched for randomized controlled trials and observational studies and analyzed viral suppression rates among children started on ART during three time periods, based on major World Health Organization (WHO) guideline changes: early (2000-2005), intermediate (2006-2009), and current (2010 and later), using random effects meta-analysis. Seventy-two studies, reporting on 51,347 children and adolescents (