Dissemin is shutting down on January 1st, 2025

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Impact Journals, Oncotarget, 23(5), p. 12111-12125, 2014

DOI: 10.18632/oncotarget.2545

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Cooperative interactions between p53 and NFκB enhance cell plasticity

Journal article published in 2014 by Alessandra Bisio ORCID, Judit Zámborszky, Sara Zaccara, Mattia Lion, Toma Tebaldi, Vasundhara Sharma ORCID, Ivan Raimondi, Federica Alessandrini, Yari Ciribilli, Alberto Inga
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The p53 and NFκB sequence-specific transcription factors play crucial roles in cell proliferation and survival with critical, even if typically opposite, effects on cancer progression. To investigate a possible crosstalk between p53 and NFκB driven by chemotherapy-induced responses in the context of an inflammatory microenvironment, we performed a proof of concept study using MCF7 cells. Transcriptome analyses upon single or combined treatments with doxorubicin (Doxo, 1.5μM) and the NFκB inducer TNF-alpha (TNF⍺, 5ng/ml) revealed 432 up-regulated (log2 FC> 2), and 390 repressed genes (log2 FC