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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 9(50), p. 3173-3174, 2006

DOI: 10.1128/aac.00427-06

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Intracellular Penetration and Activity of DX-619 in Human Polymorphonuclear Leukocytes

Journal article published in 2006 by Isabel García, Sofía Ballesta, Concepción Murillo, Evelio J. Perea, Álvaro Pascual, Álvaro Pascual ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT The intracellular penetration and activity of DX-619 in human polymorphonuclear leukocytes have been evaluated. DX-619 reached intracellular concentrations 10 times higher than the extracellular concentrations reached. Uptake was rapid, reversible, nonsaturable, and affected by environmental temperature, some metabolic inhibitors, and a soluble membrane activator. DX-619 showed intracellular activity against Staphylococcus aureus .