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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 9(50), p. 3194-3196, 2006

DOI: 10.1128/aac.00246-06

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Identification of RNase 8 as a Novel Human Antimicrobial Protein

Journal article published in 2006 by Bente Rudolph, Rainer Podschun, Hany Sahly, Sabine Schubert, Jens M. Schröder, Jürgen Harder ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT The antimicrobial activity of the human RNase A superfamily member RNase 8 was evaluated. Recombinant RNase 8 exhibited broad-spectrum microbicidal activity against potential pathogenic microorganisms (including multidrug-resistant strains) at micro- to nanomolar concentrations. Thus, RNase 8 was identified as a novel antimicrobial protein and may contribute to host defense.