American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 9(50), p. 3194-3196, 2006
DOI: 10.1128/aac.00246-06
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ABSTRACT The antimicrobial activity of the human RNase A superfamily member RNase 8 was evaluated. Recombinant RNase 8 exhibited broad-spectrum microbicidal activity against potential pathogenic microorganisms (including multidrug-resistant strains) at micro- to nanomolar concentrations. Thus, RNase 8 was identified as a novel antimicrobial protein and may contribute to host defense.