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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 9(50), p. 3098-3101, 2006

DOI: 10.1128/aac.00438-06

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Plasmid-Mediated Imipenem-Hydrolyzing Enzyme KPC-2 among Multiple Carbapenem-Resistant Escherichia coli Clones in Israel

Journal article published in 2006 by Shiri Navon-Venezia ORCID, Inna Chmelnitsky, Azita Leavitt, Mitchell J. Schwaber, David Schwartz, Yehuda Carmeli
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Carbapenem resistance in Escherichia coli is rare. We report four genetically unrelated carbapenem-resistant E. coli isolates cultured from four patients hospitalized in Tel Aviv Medical Center. PCR, sequencing, and Southern blot analysis identified KPC-2 as the imipenem-hydrolyzing enzyme in all four strains, carried on different plasmids with a possible common origin. This is the first discovery of KPC-2 in E. coli and the first report of this enzyme originating outside the United States.