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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 11(56), p. 6054-6056, 2012

DOI: 10.1128/aac.01170-12

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In Vitro Antifungal Activity of Isavuconazole against Madurella mycetomatis

Journal article published in 2012 by Wendy Kloezen, Jacques F. G. M. Meis, Ilse Curfs-Breuker, Wendy W. J. van de Sande ORCID, Ahmed H. Fahal, W. W. van de Sande
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Currently, therapy of black-grain mycetoma caused by Madurella mycetomatis consists of extensive debridement of the infected tissue combined with prolonged antifungal therapy with ketoconazole or itraconazole. In the present study, the in vitro activity of the new triazole isavuconazole toward M. mycetomatis was evaluated. Isavuconazole appeared to have high activity against M. mycetomatis , with MICs ranging from ≤0.016 to 0.125 μg/ml. Due to its favorable pharmacokinetics, isavuconazole could be a promising antifungal agent in the treatment of mycetoma.