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BioMed Central, Clinical Epigenetics, 1(8), 2016

DOI: 10.1186/s13148-016-0266-6

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DNA methylation and smoking in Korean adults: epigenome-wide association study

Journal article published in 2016 by Mi Kyeong Lee, Yoonki Hong, Sun-Young Kim, Stephanie J. London ORCID, Woo Jin Kim
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Background Exposure to cigarette smoking can increase the risk of cancers and cardiovascular and pulmonary diseases. However, the underlying mechanisms of how smoking contributes to disease risks are not completely understood. Epigenome-wide association studies (EWASs), mostly in non-Asian populations, have been conducted to identify smoking-associated methylation alterations at individual probes. There are few data on regional methylation changes in relation to smoking. Few data link differential methylation in blood to differential gene expression in lung tissue. Results We identified 108 significant (false discovery rate (FDR)