Organic-inorganic perovskite solar cells have attracted tremendous attention because of their remarkably high power conversion efficiencies (PCEs). To further improve the device performance, however, it is imperative to obtain fundamental understandings on the photo-response and long-term stability down to the microscopic level. Here, we report the first quantitative nanoscale photoconductivity imaging on two methylammonium lead triiodide (MAPbI3) thin films with different PCEs by light-stimulated microwave impedance microscopy. The intrinsic photo-response is largely uniform across grains and grain boundaries, which is direct evidence on the inherently benign nature of microstructures in the perovskite thin films. In contrast, the carrier mobility and lifetime are strongly affected by bulk properties such as the sample crystallinity. As visualized by the spatial evolution of local photoconductivity, the degradation due to water diffusion through the capping layer begins with the disintegration of large grains rather than the nucleation and propagation from grain boundaries. Our findings provide new insights to improve the electro-optical properties of MAPbI3 thin films towards large-scale commercialization. ; Comment: 23 pages, 4 figures