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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 9(57), p. 4540-4542, 2013

DOI: 10.1128/aac.00563-13

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Efficacy of Amphotericin B at Suboptimal Dose Combined with Voriconazole in a Murine Model of Aspergillus fumigatus Infection with PoorIn VivoResponse to the Azole

Journal article published in 2013 by Marcelo Sandoval-Denis, F. Javier Pastor, Javier Capilla, Josep Guarro ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT The combination of amphotericin B at a suboptimal dose (0.3 mg/kg) with voriconazole has shown efficacy in prolonging survival and reducing tissue burden in a murine model of disseminated infection by an isolate of Aspergillus fumigatus that had showed a poor in vivo response to the azole. The efficacy of the combined treatment was higher than that obtained with amphotericin B at 0.8 mg/kg.