Activation of dopamine 1 receptors in human neuronal-like cells transdifferentiated from blood circulating monocytes replicates findings from in vivo studies
Journal article published in 2016 by
Lescallette Ar,
Adam R. Lescallette,
Michael Valente,
Julien Matricon,
Robert Gardette,
Sean Seung Kwon,
Strassnig Mt,
Martin T. Strassnig,
Saunders Efh,
Erika F. H. Saunders,
Therese M. Jay 
,
Marie-Odile Krebs,
Krebs Mo,
Anne Hosmalin,
Vincent Feuillet
and other authors.
,
Marie-Odile Krebs,
Krebs Mo,
Anne Hosmalin,
Vincent Feuillet
and other authors.
Abstract
Other ; During brain development, dopamine regulates the outgrowth and retraction of neuronal extensions even before synaptic transmission occurs. Numerous studies in vivo and in vitro have shown that activation of the dopamine 1 receptor (D1R) results in retraction of the neuropil. Considering that schizophrenia is a neurodevelopmental illness in which dopamine appears to participate it is thus possible that dopamine’s effects on the neuronal structure could be related to this illness pathophysiology.