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National Academy of Sciences, Proceedings of the National Academy of Sciences, 49(111), 2014

DOI: 10.1073/pnas.1421126111

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Plasma DNA aberrations in systemic lupus erythematosus revealed by genomic and methylomic sequencing

Journal article published in 2014 by Rebecca W. Y. Chan, Peiyong Jiang, Xianlu Peng, Lai-Shan Tam ORCID, Gary J. W. Liao, Edmund K. M. Li, Priscilla C. H. Wong, Hao Sun ORCID, K. C. Allen Chan, Rossa W. K. Chiu, Y. M. Dennis Lo
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Significance Through the use of massively parallel sequencing, we have demonstrated a spectrum of plasma DNA abnormalities in patients with systemic lupus erythematosus. These abnormalities include aberrant measured genomic representations, hypomethylation, and DNA fragment size shortening. The binding of anti-double–stranded DNA antibody to plasma DNA appears to be an important factor associated with these abnormalities. These findings provide valuable insights into the biology of plasma DNA in an autoimmune disease and have potential implications for the development of new molecular markers for systemic lupus erythematosus.