Dissemin is shutting down on January 1st, 2025

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American Society for Microbiology, Journal of Virology, 10(88), p. 5864-5869, 2014

DOI: 10.1128/jvi.00145-14

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Local Control of Repeated-Dose Rectal Challenges in DNA/MVA-Vaccinated Macaques Protected against a First Series of Simian Immunodeficiency Virus Challenges

Journal article published in 2014 by Sunil Kannanganant, Salaija Gangadhara, Lilin Lai ORCID, Benton Lawson, Pamela A. Kozlowski, Harriet L. Robinson, Rama Rao Amara
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Here, we report the results of a late boost and three additional series of simian immunodeficiency virus (SIV) challenges in seven DNA/modified vaccinia virus Ankara (MVA)-vaccinated rhesus macaques who resisted a first series of rectal challenges. During 29 additional challenges delivered over 2.3 years, all animals became infected. However, 13 blips of virus in six macaques and anamnestic Env-specific rectal IgA responses in three of the six suggested that local control of infections was occurring during the serial challenge.