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BioMed Central, Genome Biology, 6(8), p. R128

DOI: 10.1186/gb-2007-8-6-r128

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Morphine effects on striatal transcriptome in mice

Journal article published in 2007 by Michal Korostynski, Marcin Piechota, Dorota Kaminska ORCID, Wojciech Solecki, Ryszard Przewlocki
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Background Chronic opiate use produces molecular and cellular adaptations in the nervous system that lead to tolerance, physical dependence, and addiction. Genome-wide comparison of morphine-induced changes in brain transcription of mouse strains with different opioid-related phenotypes provides an opportunity to discover the relationship between gene expression and behavioral response to the drug. Results Here, we analyzed the effects of single and repeated morphine administrations in selected inbred mouse strains (129P3/J, DBA/2J, C57BL/6J, and SWR/J). Using microarray-based gene expression profiling in striatum, we found 618 (false discovery rate