Herpes viruses are ubiquitous pathogens associated with high morbidity and mortality in immunocompromised individuals. Following symptomatic primary infection, all herpes viruses maintain a state of lifelong asymptomatic latent persistence in the host with sporadic symptomatic reactivation. The persistence of these viruses has been described in several tissues including stomach, intestine and colon Viral reactivation from such reservoirs may induce disease in immunocompromised individuals. We evaluated the presence of herpes viruses (EBV, HHV6 and CMV) in gastric, duodenal and colon biopsies from HIV-positive patients. Viral DNA was quantified with Taqman Real-Time PCR