Dissemin is shutting down on January 1st, 2025

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BioMed Central, Clinical Epigenetics, 1(7), 2015

DOI: 10.1186/s13148-015-0088-y

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Tobacco smoking is associated with methylation of genes related to coronary artery disease

Journal article published in 2015 by Rebecca V. Steenaard, Symen Ligthart, Lisette Stolk, Marjolein J. Peters, Joyce B. van Meurs ORCID, Andre G. Uitterlinden, Albert Hofman, Oscar H. Franco, Abbas Dehghan ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Background Tobacco smoking, a risk factor for coronary artery disease (CAD), is known to modify DNA methylation. We hypothesized that tobacco smoking modifies methylation of the genes identified for CAD by genome-wide association study (GWAS). Results We selected genomic regions based on 150 single-nucleotide polymorphisms (SNPs) identified in the largest GWAS on CAD. We investigated the association between current smoking and the CpG sites within and near these CAD-related genes. Methylation was measured with the Illumina Human Methylation 450K array in whole blood of 724 Caucasian subjects from the Rotterdam Study, a Dutch population based cohort study. A total of 3669 CpG sites within 169 CAD-related genes were studied for association with current compared to never smoking. Fifteen CpG sites were significantly associated after correction for multiple testing (Bonferroni-corrected p value