Up-regulation of EphB and ephrinB expression in rhabdomyosarcoma tumours
Journal article published in 2008 by
Berardi Ac,
S. Marsilio,
C. Rofani,
O. Salvucci,
P. Altavista,
Perla Fm,
F. Diomedi Camassei,
S. Uccini,
G. Kokai,
L. Landuzzi,
Mcdowell Hp,
C. Dominici
Abstract
Background: Increased expression of Eph receptors and their ephrin ligands has been implicated in promoting angiogenesis and tumour progression in several malignancies. Here the expression of mRNA for ephrin-B and EphB receptors in rhabdomyosarcoma (RMS) cell lines and primary tumours was investigated. Materials and Methods: Expression of mRNA for ephrin-B and EphB receptors in RMS cell lines and primary tumours was measured by real-time RT-PCR and compared with the expression in normal striated muscle. Results: A dysregulation of both ligands and receptors was found in all cell lines. In embryonal tumours, overexpression of ephrin-B1 correlated with overexpression of EphB1 (r=0.97, p