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Springer Nature [academic journals on nature.com], Cell Research, 5(23), p. 595-596, 2013

DOI: 10.1038/cr.2013.24

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Love and death: microglia, NLRP3 and the Alzheimer's brain

Journal article published in 2013 by Tobias Goldmann ORCID, Tuan Leng Tay, Marco Prinz
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Microglia were previously attributed to be vital brain guardians for neuronal survival and synaptic pruning during development as well as for the brain's fight against environmental pathogens. A new report in Nature by the Heneka, Latz and Golenbock groups, however, sheds new light on these distinct myeloid cells by revealing their deadly nature for mature neurons during neurodegeneration.