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Lippincott, Williams & Wilkins, Journal of Acquired Immune Deficiency Syndromes, 4(62), p. 436-440, 2013

DOI: 10.1097/qai.0b013e31828175ed

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Adverse events in an integrated, home-based treatment program for MDR-TB and HIV in KwaZulu-Natal, South Africa

Journal article published in 2013 by James C. M. Brust, N. Sarita Shah, Theo L. van der Merwe, Sheila Bamber, Yuming Ning, Moonseong Heo, Anthony P. Moll, Marian Loveday, Umesh G. Lalloo, Gerald H. Friedland, Neel R. Gandhi ORCID
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Abstract

Most patients with multidrug-resistant tuberculosis (MDR-TB) in South Africa are HIV-infected, but the safety and tolerability of co-treatment is unknown. We reviewed all adverse events (AEs) for MDR-TB patients in a home-based treatment program in rural KwaZulu-Natal. Of 91 MDR-TB patients, 74 (81%) were HIV-positive and receiving antiretroviral therapy (ART). AEs were common but most were mild and did not require therapy modification. The most common severe AEs were hypothyroidism (36%) and psychosis (5%). Patients receiving concurrent ART did not experience AEs more frequently than those on MDR-TB therapy alone. Concurrent treatment for MDR-TB/HIV can be safely administered in a home-based care setting.