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Lippincott, Williams & Wilkins, PAIN, 1(111), p. 38-50, 2004

DOI: 10.1016/j.pain.2004.05.025

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The functional expression of mu opioid receptors on sensory neurons is developmentally regulated; morphine analgesia is less selective in the neonate

Journal article published in 2004 by Reema Nandi, Daniel Beacham, Jacqueta Middleton, Martin Koltzenburg ORCID, Rf Howard, Maria Fitzgerald
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Opioid requirements in neonatal patients are reported to be lower than older infants and this may be a reflection of the developmental regulation of opioid receptors. In this study we have investigated the postnatal regulation of Mu opioid receptor (MOR) function in both rat lumbar dorsal root ganglion (DRG) cultures and behavioural mechanical and thermal reflex tests in rat pups. Immunostaining with MOR and selective neurofilament (NF200) antibodies was combined with calcium imaging of MOR function in cultured neonatal and adult rat dorsal root ganglion cells. Calcium imaging showed that a significantly greater number of neonatal DRG neurons expressed functional MOR compared to adult (56.5 +/- 3.4 versus 39.9 +/- 1.5%, n = 8, mean +/- SEM, P