Published in
American Society for Microbiology, Journal of Virology, 2(83), p. 1152-1155, 2009
DOI: 10.1128/jvi.01627-08
Links
- ORCID
- ORCID
- American Society for Microbiology | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [hdl.handle.net] | PDF
- [europepmc.org] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [iris.unito.it] | PDF
Tools
Genome analysis of small-ruminant lentivirus genotype E: a caprine lentivirus with natural deletions of the dUTPase subunit, vpr-like accessory gene, and 70-base-pair repeat of the U3 region
,
Elena Grego,
Luigi Bertolotti,
Daniele De Meneghi,
Sergio Rosati
Full text: Download
Abstract
ABSTRACT The nucleotide sequence of the highly divergent small-ruminant lentivirus genotype E has been determined. The full genome consists of 8,418 nucleotides and lacks two large portions corresponding nearly to the entire dUTPase subunit of the pol and vpr -like accessory genes. Moreover, the 70-bp repeat of the U3 region of the long terminal repeat was observed to be deleted. Interestingly, this lentivirus genotype is able to persist in a local breed population, and retrospective analysis revealed its presence in milk samples collected in 1999. gag sequences obtained from a flock coinfected with the B1 and E genotypes revealed that the evolutionary rates of the two viruses were quite similar. Since a reduced viral load and/or disease progression was observed for viruses with artificially deleted dUTPase and vpr -like genes, it is proposed that this viral cluster be designated a low-pathogenicity caprine lentivirus.