Since Photodynamic therapy(pDT) is able to increase tbe antitumor immunity, in OtD' laboratory we examine the antitumor effect of combination of PDT,witb photoactivated Aluminiwn disulfonated Phthalocianinc(ALS2Pc),adoptive immtmotherapy, with immune lymphocytes, and chcmotherapy on aggressive murine tumor. Mice bearing Ll2lO tumor were treated at day +4 with PDT ( SmgfKg of AlS2Pc and IOOmW/cm2 x IO' of exposure of laser light 24hrs. later),at day +6 with Adriamycin(ADR 2mgIKg) and al day + 7 with immlllle lymphocytes(lL),collected from Ll210 bearing mice pretreated with POT(2xI07 cells).The results show that tbe combination ADR + POT + lL demonstrnte5 a significant synergistic antitwnor effect while the chemotherapy treatment with low dose of the drug and tbe adotive imnnUlotherapy treatment are slight1y effective. The same positive results were obtained with the combination of PDT,Cisplatin(COOP 2mg!Kg) and lL,while the CDOP treatment alone and the Il treatment alone are slight1y effective. In conc1usion these results suggest tbat il is possible to completely cure animals bearing advanced tumors, witb a combined therapy, POT + adoptive inunWlOtberapy + low dose chemotberapy.