Serotype-Specific Changes in Invasive Pneumococcal Disease after Pneumococcal Conjugate Vaccine Introduction: A Pooled Analysis of Multiple Surveillance Sites

Thoon, Koh Cheng; Feikin, Daniel R.; Whitney, Cynthia G.; Link-Gelles, Ruth; Feikin, D. R.; Link-Gelles, R.; Adegbola, R. A.; Cherian, T.; Cherian, Thomas; Kagucia, Eunice W.; Agocs, M.; Ampofo, K.; de Wals, P.; Andrews, N.; Barton, T.; Benito, J.; Loo, Jennifer D.; Broome, C. V.; Bruce, M. G.; Bulkow, L. R.; Byington, C. L.; Camou, T.; Levine, Orin S.; Cook, H.; Cotter, S.; Puhan, Milo A.; Dagan, R.; Deceuninck, G.; Denham, B.; Edwards, G.; Eskola, J.; Fitzgerald, M.; O'brien, Katherine L.; Moore, Matthew R.; Galanakis, E.; Garcia gabarrot, G.; Garcia garcia, J. J.; Gene, A.; Gomez, B.; Heffernan, H.; Hennessy, T. W.; Heuberger, S.; Hilty, M.; van der Ende, A.; Jayasinghe, S.; Kagucia, E. W.; Kellner, J. D.; van der Linden, M. P. G.; Ingels, and serotype replacement group Helene; Klein, N. P.; Kormann klement, A.; von Gottberg, A.; Kozakova, J.; von Kries, R.; Krause, V.; Kriz, P.; Lambertsen, L.; Yee, A.; Levine, O. S.; Lepoutre, A.; Zaidi, A. K. M.; Lipsitch, M.; Loo,; Lopez vega, M.; Lovgren, M.; Maraki, S.; Mason, E. O.; Mcintyre, P. B.; Menzies, R.; Messina, A.; O’Brien, Katherine L.; Miller, E.; Moore, M. R.; Motlova, J.; Group, Serotype Replacement Study; Mintegi, Santiago; Moulton, L. H.; Mühlemann, K.; Muñoz-Almagro, C.; Murdoch, D. R.; Puhan,; Mhlemann, K.; Park, D. E.; Muoz almagro, C.; Reingold, A. L.; Sa leao, R.; Johns Hopkins Bloomberg School of Public Health, Baltimore Maryland United States of America; Sanyal, A.; Smith, P. G.; Spanjaard, L.; Techasaensiri, C.; Thompson, R. E.; Thoon, K. C.; Tyrrell, G. J.; Valentiner branth, P.; Vanderkooi, O. G.; Varon, E.; Verhaegen, J.; Vestrheim, D. F.; Vickers, I.; Waight, P.; Weatherholtz, R.; Weiss, S.; Whitney, C. G.; Grp, Serotype Replacement Study; National Center for Emerging and Zoonotic and Infectious Diseases, Centers for Disease Control and Prevention Atlanta Georgia United States of America

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Public Library of Science, PLoS Medicine, 9(10), p. e1001517, 2013

DOI: 10.1371/journal.pmed.1001517

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Serotype-Specific Changes in Invasive Pneumococcal Disease after Pneumococcal Conjugate Vaccine Introduction: A Pooled Analysis of Multiple Surveillance Sites

Journal article published in 2013 by Koh Cheng Thoon, Daniel R. Feikin, Cynthia G. Whitney, Ruth Link-Gelles, D. R. Feikin, R. Link-Gelles, R. A. Adegbola, T. Cherian, Thomas Cherian, Eunice W. Kagucia, M. Agocs, K. Ampofo, P. de Wals, N. Andrews, T. Barton and other authors.

This paper is made freely available by the publisher.

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Abstract

Journal Article; Research Support, Non-U.S. Gov't ; BACKGROUND: Vaccine-serotype (VT) invasive pneumococcal disease (IPD) rates declined substantially following introduction of 7-valent pneumococcal conjugate vaccine (PCV7) into national immunization programs. Increases in non-vaccine-serotype (NVT) IPD rates occurred in some sites, presumably representing serotype replacement. We used a standardized approach to describe serotype-specific IPD changes among multiple sites after PCV7 introduction. METHODS AND FINDINGS: Of 32 IPD surveillance datasets received, we identified 21 eligible databases with rate data ??? 2 years before and ??? 1 year after PCV7 introduction. Expected annual rates of IPD absent PCV7 introduction were estimated by extrapolation using either Poisson regression modeling of pre-PCV7 rates or averaging pre-PCV7 rates. To estimate whether changes in rates had occurred following PCV7 introduction, we calculated site specific rate ratios by dividing observed by expected IPD rates for each post-PCV7 year. We calculated summary rate ratios (RRs) using random effects meta-analysis. For children

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Serotype-Specific Changes in Invasive Pneumococcal Disease after Pneumococcal Conjugate Vaccine Introduction: A Pooled Analysis of Multiple Surveillance Sites

Abstract