Gray mold caused by Botrytis cinerea is the main postharvest decay of table grapes and it is generally considered the most important postharvest pathogen. Due to the increased consumer demand for healthy/organic food products, natural inhibitors for pathogenic microorganisms have been explored from plant extracts. In the present investigation, the ability of pomegranate (Punica granatum L.) peel and sumac (Rhus coriaria L.) fruit and leaf extracts to inhibit the decay of table grape (cv. Italia) berries was assessed. Different extraction methods were applied on plant tissues and extracts were chemically characterized for their total phenol and anthocyanin contents. Furthermore, qualitative analyses of the same compounds were obtained through UHPLC-PDA-ESI/MSn. Both in-vitro and in-vivo essays were performed in order to assess the antifungal activity of the extracts. The ethanolic pomegranate peel extract was the richest in phenols (66.97 g Gallic Acid Equivalents/kg) while the ethanolic extract and the aqueous extract from sumac fruit showed the highest anthocyanin amounts (171.96 and 94.92 mg Cyanidin 3-Glucoside Equivalents/kg, respectively). The ethanolic pomegranate peel extract was the most efficient against Botrytis rot on artificially inoculated berries completely inhibiting the pathogen at different intervals of time between treatment and pathogen inoculation (0-12-24 hours). The concentrated sumac leaf extract reached the 100% of rot inhibition when B. cinerea spores were inoculated after 24 hs from treatment, while sumac fruit extract at the same time interval showed a 75% of rot reduction.