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BioMed Central, Arthritis Research and Therapy, 1(17), 2015

DOI: 10.1186/s13075-015-0631-4

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Bone geometry of the hip is associated with obesity and early structural damage – a 3.0 T magnetic resonance imaging study of community-based adults

Journal article published in 2015 by Andrew J. Teichtahl, Yuanyuan Wang, Sam Smith, Anita E. Wluka, Donna Urquhart, Michael Zhu ORCID, Graham G. Giles ORCID, Flavia M. Cicuttini, Richard O’sullivan
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Introduction The mechanism by which obesity increases the risk of hip osteoarthritis is unclear. One possibility may be by mediating abnormalities in bony geometry, which may in turn be associated with early structural abnormalities, such as cartilage defects and bone marrow lesions. Methods One hundred and forty one older adults with no diagnosed hip osteoarthritis had weight and body mass index measured between 1990 and 1994 and again in 2009 to 2010. Acetabular depth and lateral centre edge angle, both measures of acetabular over-coverage, as well as femoral head cartilage volume, cartilage defects and bone marrow lesions were assessed with 3.0 T magnetic resonance imaging performed in 2009 to 2010. Results Current body mass index, weight and weight gain were associated with increased acetabular depth and lateral centre edge angle (all P ≤ 0.01). For every 1 mm increase in acetabular depth, femoral head cartilage volume reduced by 59 mm 3 (95% confidence interval (CI) 20 mm 3 to 98 mm 3 , P