Recent advances in the synthesis of water-soluble homoscorpionates of the tris(pyrazol-1-yl)methane type as well as of their water-soluble metal complexes are reviewed. Moreover, the application of these tris(pyrazol-1-yl)methane metal complexes as catalysts for the oxidative functionalization of inexpensive and abundant alkanes to value-added products and other industrially significant reactions is addressed. We also focus on the main biological (antiproliferative and antimicrobial) applications of such C-scorpionate-type complexes. ; info:eu-repo/semantics/publishedVersion