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American Society for Microbiology, Journal of Bacteriology, 3(165), p. 813-818, 1986

DOI: 10.1128/jb.165.3.813-818.1986

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Classification of Histoplasma capsulatum isolates by restriction fragment polymorphisms.

Journal article published in 1986 by R. D. Vincent, R. Goewert, W. E. Goldman ORCID, G. S. Kobayashi, A. M. Lambowitz, G. Medoff
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Twenty isolates of the dimorphic, pathogenic fungus Histoplasma capsulatum were divided into three classes based on comparisons of restriction enzyme digests of their mitochondrial DNA and rDNA. The majority of isolates, including most North American strains and the African H. capsulatum var. duboisii variants, belong to class 2. Isolates from Central America and South America make up class 3. The attenuated Downs strain is the only member of class 1.