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American Society of Hematology, Blood, 25(127), p. 3253-3259, 2016

DOI: 10.1182/blood-2016-02-696310

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Homozygous Calreticulin mutations in patients with myelofibrosis lead to acquired myeloperoxidase deficiency

Journal article published in 2016 by Alexandre P. A. Theocharides ORCID, Pontus Lundberg, Asvin K. K. Lakkaraju ORCID, Veronika Lysenko, Renier Myburgh, Adriano Aguzzi, Radek C. Skoda, Markus G. Manz ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Key PointsAcquired MPO deficiency in patients with MPN is uniquely associated with homozygous CALR mutations. In line with a posttranscriptional defect, MPO deficiency results from reduced MPO protein levels, but not from decreased MPO mRNA.