Published in
American Society of Hematology, Blood, 24(127), p. 3015-3025, 2016
DOI: 10.1182/blood-2015-11-682906
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IL-4 enhances expression and function of surface IgM in CLL cells
Journal article published in 2016 by
Maria M. Aguilar-Hernandez,
Matthew D. Blunt,
Rachel Dobson,
Alison Yeomans,
Stephen Thirdborough,
Marta Larrayoz 
,
Lindsay D. Smith,
Adam Linley,
Jonathan C. Strefford,
Andrew Davies,
Peter M. W. Johnson,
Natalia Savelyeva,
Mark S. Cragg,
Francesco Forconi,
Graham Packham
and other authors.
,
Lindsay D. Smith,
Adam Linley,
Jonathan C. Strefford,
Andrew Davies,
Peter M. W. Johnson,
Natalia Savelyeva,
Mark S. Cragg,
Francesco Forconi,
Graham Packham
and other authors.
This paper is made freely available by the publisher.
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Abstract
Key Points IL-4 treatment augments sIgM expression and subsequent downstream signalling in a JAK3/STAT6 dependent manner within CLL samples. IL-4 exposure partially opposes the activity of Bruton tyrosine kinase or PI3K inhibitors on sIgM-mediated signalling.