American Society of Hematology, Blood, 24(127), p. 3015-3025, 2016
DOI: 10.1182/blood-2015-11-682906
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Key Points IL-4 treatment augments sIgM expression and subsequent downstream signalling in a JAK3/STAT6 dependent manner within CLL samples. IL-4 exposure partially opposes the activity of Bruton tyrosine kinase or PI3K inhibitors on sIgM-mediated signalling.