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Elsevier, Molecular Immunology, 4(56), p. 693-697, 2013

DOI: 10.1016/j.molimm.2013.07.005

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Conformational plasticity at the IgE-binding site of the B-cell receptor CD23☆

Journal article published in 2013 by Balvinder Dhaliwal, Marie O. Y. Pang, Daopeng Yuan, Norhakim Yahya, Stella M. Fabiane, James M. McDonnell, Hannah J. Gould ORCID, Andrew J. Beavil ORCID, Brian J. Sutton
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

IgE antibodies play a central role in allergic disease. They recognize allergens via their Fab regions, whilst their effector functions are controlled through interactions of the Fc region with two principal cell surface receptors, FcɛRI and CD23. Crosslinking of FcɛRI-bound IgE on mast cells and basophils by allergen initiates an immediate inflammatory response, while the interaction of IgE with CD23 on B-cells regulates IgE production. We have determined the structures of the C-type lectin "head" domain of CD23 from seven crystal forms. The thirty-five independent structures reveal extensive conformational plasticity in two loops that are critical for IgE binding.