Dissemin is shutting down on January 1st, 2025

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Wiley, Obesity, 11(20), p. 2213-2219, 2012

DOI: 10.1038/oby.2012.138

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Increased death of adipose cells, a path to release cell free DNA into systemic circulation of obese women

Journal article published in 2012 by Maricela Haghiac, Sylvie Hauguel de Mouzon, Neeta L. Vora ORCID, Subhabrata Basu, Kirby L. Johnson, Larraine Presley, Diana W. Bianchi, Sylvie Hauguel-De Mouzon
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Remodeling of adipose tissue is required to support the expansion of adipose mass. In obesity, an increased death of adipocytes contributes to the accelerated cellular turnover. We have shown that obesity in pregnancy is associated with metabolic and immune alterations in the adipose tissue. In this study we characterized the mechanisms responsible for increased death of adipose cells of pregnant obese women and its functional consequences. We postulated that a higher turnover of dead cells in white adipose tissue of obese women would translate into release of cell free DNA (cfDNA) into their systemic circulation.