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Elsevier, Tetrahedron Letters, 17(57), p. 1892-1894, 2016

DOI: 10.1016/j.tetlet.2016.03.059

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Isolation and characterization of santolinoidol, a bisabolene sesquiterpene from Achillea santolinoides subsp wilhelmsii (K. Koch) Greuter

Journal article published in 2016 by Layal Fahed, Marc El Beyrouthy, Naïm Ouaini, Véronique Eparvier, Didier Stien ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The essential oil (EO) obtained by hydrodistillation of aerial parts of Lebanese Achillea santolinoides subsp wilhelmsii (K. Koch) Greuter was analyzed by GC and GC–MS. The identity of the second major compound was uncertain. Its structure was elucidated using 1D and 2D NMR spectroscopy as well as MS data. It appeared to be a new sesquiterpene with a 1-oxa-bicyclo[5,4,0]-undecane skeleton which was named santolinoidol. The EO revealed interesting antimicrobial potential particularly against Trichophyton species, Staphylococcus aureus and Methicillin-resistant Staphylococcus aureus (MRSA) with MIC values ranging from 16 to 128 μg/ml.